A prospective, multicenter cohort study establishing a registry to analyze the cellular and immunoregulatory profile of platelet-rich plasma preparations used to treat knee osteoarthritis.
Lead site Mayo Clinic; Principal Investigator Dr. Cole. Funded by the Rush Department of Orthopedics. (N=80)
Prospective, multi-center cohort registry study
Adults age 18 or older at the time of consent with a diagnosis of osteoarthritis (Kellgren Lawrence grade 1 to 4) who have chosen elective PRP therapy.
To characterize the cell and immunoregulatory factor profile in PRP preparations, and in synovial fluid when effusion is present, and to correlate these findings to patient-reported pain and function outcomes.
Patients receive an elective PRP injection at their baseline clinic visit using the Arthrex ACP kit. The study combines retrospective chart abstraction with prospective patient-reported outcomes, including KOOS, PROMIS Pain Interference, PROMIS Physical Function, SANE, VAS, and Tegner scores.